Gene Transfer and Expression of Platelet-derived Growth Factors Modulate Periodontal Cellular Activity
نویسندگان
چکیده
منابع مشابه
Characteristics of yak platelet derived growth factors-alpha gene and expression in brain tissues.
BACKGROUND Platelet derived growth factors (PDGFs) are key components of autocrine and paracrine signaling, both of which play important roles in mammalian developmental processes. PDGF expression levels also relate to oxygen levels. The characteristics of yak PDGFs, which are indigenous to hypoxic environments, have not been clearly described until the current study. MATERIALS AND METHODS We...
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In a baboon graft model of arterial intimal thickening, smooth muscle cells (SMC) have been observed to proliferate underneath an intact monolayer of endothelium and in the absence of platelet adherence. Because platelets are not present and therefore cannot be a major source of growth stimulus, we have proposed that the vascular wall cells in the graft intima express mitogens and regulate SMC ...
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Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in gastrulation and in the development of the cranial and cardiac neural crest, gonads, lung, intestine, skin, CNS, and skelet...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2001
ISSN: 0022-0345,1544-0591
DOI: 10.1177/00220345010800030901